The genotoxicity and systemic toxicity of a pharmaceutical effluent in Wistar rats may involve oxidative stress induction

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The genotoxicity and systemic toxicity of a pharmaceutical effluent in Wistar rats may involve oxidative stress induction

There is scarcity of information on the possible mechanisms of pharmaceutical effluent induced genotoxicity and systemic toxicity. This study investigated the genotoxicity and systemic toxicity of a pharmaceutical effluent in Wistar rats. Rats were orally treated with 5-50% concentrations of the effluent for 28 days. At post-exposure, blood, liver, kidney and bone marrow cells were examined for...

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Genotoxicity assessment of a pharmaceutical effluent using four bioassays

Pharmaceutical industries are among the major contributors to industrial waste. Their effluents when wrongly handled and disposed of endanger both human and environmental health. In this study, we investigated the potential genotoxicity of a pharmaceutical effluent, by using the Allium cepa, mouse- sperm morphology, bone marrow chromosome aberration (CA) and micronucleus (MN) assays. Some of th...

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Cadmium-Induced Nephrotoxicity via Oxidative Stress in Male Wistar Rats and Capsaicin Protects Its Toxicity

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Oxidative Stress by Tartrazine in the Testis of Wistar Rats

The aim is to study the effect of Tartrazine (E102) – synthetic food colour – on the antioxidant status of testis of Wistar rats. Twelve male Wistar rats were grouped into 2 groups of six each – Control and Tartrazine-treated groups. Control group was orally administered with water alone while the experimental group was orally administered with tartrazine dissolved in water. The treatment was c...

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ژورنال

عنوان ژورنال: Toxicology Reports

سال: 2015

ISSN: 2214-7500

DOI: 10.1016/j.toxrep.2015.09.004